Acute toxicity of ibogaine and noribogaine
Medicina September 28, 2008 Asta Kubilienė, Rūta Marksienė, Saulius Kazlauskas et al. 26 citations
Ibogaine is 2.4 times more toxic than noribogaine in mice. The median lethal dose (LD50) of ibogaine is 263 mg/kg of body mass, while noribogaine's LD50 is 630 mg/kg. At 500 mg/kg of ibogaine, all mice died; at 300 mg/kg, three out of four died; at 100 mg/kg, none died. For noribogaine, 500 mg/kg caused no deaths, 700 mg/kg killed three out of four, and 900 mg/kg killed all. Low doses of either substance did not affect mouse behavior; higher doses caused convulsions, nervous behavior, and limb paralysis.