Ibogaine and Noribogaine: Structural Analysis and Stability Studies. Use of LC‐MS to Determine Alkaloid Contents of the Root Bark of Tabernanthe Iboga
Journal of Liquid Chromatography & Related Technologies March 1, 2007 Violeta Kontrimavičiūtė, Olivier Mathieu, Laurence Balas et al. 7 citations
Ibogaine and noribogaine, alkaloids from the Tabernanthe iboga shrub, break down when exposed to daylight or 254 nm UV light in methanol, forming oxidation products such as ibochine, iboluteine, and their desmethoxy analogues. A possible lactam derivative also appears under UV. Analysis of root bark from one shrub using liquid chromatography-mass spectrometry detected seven alkaloids: ibochine, ibogaline, iboluteine, ibogaine, ibogamine, voacangine, and an unidentified compound at m/z 309. Ibogaine was the most abundant alkaloid, with concentrations between 1.8 and 5.93 mg/g. The peak areas of ibogaline, ibogamine, and voacangine were 11.9%, 21.5%, and 30.5% of ibogaine's, respectively.