THE PSYCHEDELIC AND KETAMINE RENAISSANCE IN THE FACE OF THE CRISIS IN MODERN PSYCHIATRY
International Journal of Innovative Technologies in Social Science June 15, 2026 Julia Osipowska, Marlena Kwolek, Alicja Judzińska et al.
Contemporary psychiatry faces stagnation by relying on daily-dose pharmacotherapy for chronic symptom management. Psychedelics and ketamine offer rapid-acting alternatives targeting underlying neurobiological mechanisms rather than mere symptom suppression. This multidisciplinary review synthesizes knowledge on 5-HT2A receptor agonism, next-generation non-hallucinogenic psychoplastogens, and ethical-legal challenges for global and Polish healthcare. It compares classic psychedelics with conventional treatments like SSRIs, examining socioeconomic factors affecting therapy democratization. The psychedelic renaissance requires a new psychiatric language rooted in neuroplasticity and connectivity. Scalability depends on isolating plasticity effects and using short-acting tryptamines to reduce clinical burdens. For Poland to participate, urgent legislative harmonization and ethical frameworks addressing patient suggestibility are needed.