Transient multidomain functional improvement in advanced Alzheimer's disease following high-dose psilocybin-containing mushroom administration: a case report.
Frontiers in neuroscience January 1, 2026 Marcos Lago, Mariana Cerveira, Joe Xavier Simonet 1 citation
A single case report describes an 80-year-old woman with a 10-year history of Alzheimer's disease and severe functional decline who showed temporary improvements in multiple domains after taking 5 grams of psilocybin-containing mushrooms. Before the intervention, she had urinary incontinence, difficulty walking, minimal speech, and required help with daily activities. About 19 hours after administration, she began speaking spontaneously about her life. Over the following days and weeks, she regained bladder control, walked better, dressed herself, showed more emotion, engaged in conversations, and recalled recent social interactions. The authors suggest that some functional capacity may persist even in late-stage Alzheimer's and can become temporarily accessible under certain conditions, but the findings do not indicate disease reversal.