PsiConnect: Multimodal Neuroimaging of Context-Dependent Brain and Behaviour Dynamics under Psilocybin.
Scientific data May 21, 2026 Leonardo Novelli, Devon Stoliker, Tamrin Barta et al.
PsiConnect is a large-scale neuroimaging study that investigates how psilocybin affects brain activity and subjective experience depending on context. Sixty-two participants received a 19 mg dose of psilocybin and underwent functional, structural, and diffusion-weighted MRI, as well as EEG, before and after administration. Scans included resting-state and three naturalistic conditions: guided meditation, music listening, and movie watching. Half of the participants completed an 8-week meditation training program, allowing examination of interactions between meditation, psilocybin, and brain function. Multi-echo fMRI improved signal quality. Behavioral and self-report measures captured acute and long-term effects, with follow-ups up to one year. Data is openly shared to support future research.