Associations between psychedelic use and migraine history in Swedish twins.
Journal of psychopharmacology (Oxford, England) May 1, 2026 Otto Simonsson, Sunjuri Sun, Laura W Wesseldijk et al.
In a large twin study using the Swedish Twin Registry, people who reported using psychedelics had lower odds of having a history of migraine. Among identical twins, the twin who used psychedelics was less likely to have migraine than their co-twin who did not. The association was significant in males but not in females. These results suggest a possible link between psychedelic use and reduced migraine likelihood, with sex differences that need further study.