Veda S Vyakaranam

From the Thomas Jefferson University (J.C.); St. Vincent's Hospital Alcohol and Drug Service (K.J.S., L.A.), Sydney, Australia; National Drug and Alcohol Research Centre (NDARC) (K.J.S., L.A.), The University of New South Wales, Randwick, Australia; New South Wales Drug and Alcohol Clinical Research and Improvement Network (DACRIN) (K.J.S., L.A.), c/o the Ministry of Health, Sydney, Australia; Jefferson Integrated Magnetic Resonance Imaging Center (JIMRIC) (V.S.V.), Thomas Jefferson University, Philadelphia-19107, USA and St. Vincent's Clinical School (J.B), University of New South Wales, Sydney, Australia.

Papers

"Large-Scale and Local Functional Connectivity Changes Following Psilocybin Administration in Methamphetamine Use Disorder.

AJNR. American journal of neuroradiology April 24, 2026 Joga Chaganti, Krista J Siefried, Veda S Vyakaranam et al.

In individuals with methamphetamine use disorder, psilocybin administration alongside psychotherapy led to measurable reorganization of large-scale brain networks and local neural synchrony. After the intervention, connectivity within and between attentional, default mode, and salience networks shifted significantly, and local synchrony increased in frontal and sensorimotor regions. Greater reductions in methamphetamine use correlated with recovery of frontostriatal and attentional connectivity, while reduced psychological distress was linked to strengthened integration of attentional and prefrontal-striatal circuits. These findings suggest psilocybin may promote network-level plasticity in stimulant addiction and support the potential of resting-state fMRI metrics as biomarkers of such change.

DOI: 10.3174/ajnr.a9364 Full text