Progress in neuro-psychopharmacology & biological psychiatry
February 2, 2018
Simon Reiche, Leo Hermle, Stefan Gutwinski et al.
125 citations
Anxiety and depression are common in people with life-threatening diseases, harming quality of life and prognosis. Serotonergic hallucinogens like LSD and psilocybin were first studied in the 1960s, and interest has recently revived. A systematic review of clinical trials from 1960 to 2017 identified 11 eligible trials with 445 participants: 7 on LSD (323 participants), 3 on psilocybin (92), and 1 on DPT (30). Four more recent randomized controlled trials (104 participants) had higher methodological quality than earlier studies. Evidence supports that these substances reduce anxiety and depression in patients with life-threatening diseases, with anecdotal reports of improved quality of life and reduced fear of death. Side effects were low in studies following safety guidelines.
Frontiers in Psychiatry
November 4, 2021
Ricarda Evens, Simon Reiche, Roman M. Marek et al.
16 citations
During the early COVID-19 pandemic, a survey of over 5,000 people across five languages found that among 1,375 who had used psychedelics in 2019 or 2020, 642 (46.6%) continued using them during the pandemic. Usage shifted away from settings outside the home, and motives changed: less curiosity, celebration, or social influence, more boredom. Positively connoted, often pro-social experiences increased, and two thirds of pandemic users said psychedelics helped them cope with the pandemic at least slightly. The changes likely reflect pandemic restrictions and a possible shift toward safer settings and self-selection.
Psychopharmacology
June 10, 2026
Julian Kirsch, C. Poppe, Anne Beck et al.
Most people with alcohol use disorder (AUD) are aware of psychedelic research and would be willing to try psychedelic therapy, but their openness depends heavily on expecting it to succeed. In a mixed-method study of 112 participants from two non-psychedelic clinical trials and 10 patients from addiction outpatient services, 62.5% knew about psychedelic research and 64.3% were willing to join a psychedelic therapy trial. Willingness was strongly linked to higher expectations of research success, not to age or knowledge alone. Interviews revealed a spectrum of attitudes shaped by perceived therapeutic potential, fears of addiction or loss of control, personal and societal experiences with substances, and media exposure. Expectation of benefit was central to openness.
The International journal on drug policy
April 1, 2022
Antonia Bendau, Leonard Viohl, Moritz Bruno Petzold et al.
During the early COVID-19 pandemic, use of party drugs (stimulants, dissociatives, GHB/GBL) shifted substantially. Among 1,231 users surveyed, 48.0–64.8% ceased or decreased use, 11.9–25.5% maintained, and 23.6–29.1% increased consumption. MDMA/ecstasy showed the strongest decrease; GHB/GBL and dissociatives the highest increase. Price, quality, and supply remained mostly unaffected. Mood-related motivations (e.g., feeling exhilarated or high) were common before and during the pandemic, but social and mood-related reasons declined while coping with boredom rose. 16.4–35.6% found drug use helpful for pandemic-related stressors, which was linked to increased consumption. The findings suggest that users who increased use as a coping strategy may need targeted preventive measures.