Contemplating versus having used psychedelics in bipolar disorder - What makes the difference?
Journal of affective disorders February 1, 2026 Lauren N Vale, Maya Ibrahim, Leonardo Fávaro-pereira et al. 1 citation
People with bipolar disorder who have used classic psychedelics like psilocybin or LSD hold more positive attitudes toward these substances and score higher on openness to experience compared to those who are only considering use. The two groups do not differ in sociodemographic background or mental health status. Those who have used psychedelics endorse certain motives for use more strongly, while those contemplating use express greater concerns about potential negative effects. The findings suggest that prior psychedelic experience shapes perceptions and motivations, and highlight topics for discussion with individuals with bipolar disorder who may consider psychedelic use, including in clinical trials.