Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood.
Psychopharmacology bulletin April 8, 2025 Keming Gao, Buket Koparal, Evrim Bayrak Oruc et al. 99 citations
A patient with treatment-resistant depression and multiple comorbid conditions (generalized anxiety disorder, eating disorder, post-traumatic stress disorder, and borderline personality disorder) experienced some short-term benefit from electroconvulsive therapy and ketamine infusion. Over a ten-year period from adolescence to adulthood, she had two separate periods of two-year stability, first with compounded ketamine intranasal spray and later with intranasal esketamine. She has been relatively stable without hospitalization or suicide attempt for more than two years on esketamine, suggesting that patients with complex treatment-resistant depression may benefit from ketamine-based treatments at different developmental stages.