Psychedelics: Historical Context, Emerging Science, and Future Clinical Frontiers
Journal of Mental Health Disorders April 18, 2026 Vipul Janardan, Amit Khanna, Om Prakash et al.
Psychedelics like psilocybin, LSD, and DMT show therapeutic promise for mental health conditions such as treatment-resistant depression, PTSD, and addiction, based on studies since 2020. This commentary synthesizes historical usage, current neuroscientific and clinical evidence, and explores ethical and regulatory challenges for future medical integration. Rigorous, ethically guided scientific validation is required.