Lysergic Acid Diethylamide extends lifespan in Caenorhabditis elegans
bioRxiv Preprint Server June 16, 2025 Beatriz de S. Carrilho, Aline Duarte, Isabelle Martins et al. preprint
Lysergic acid diethylamide (LSD) extends lifespan and reduces age-related lipofuscin accumulation in the roundworm Caenorhabditis elegans, suggesting delayed aging. LSD produces effects similar to caloric restriction, such as reduced reproduction and smaller body size, without decreasing food intake. LSD also alters lipid stores and other cellular markers linked to nutrient-sensing pathways. These findings indicate that LSD engages evolutionarily conserved longevity pathways and may serve as a tool for studying serotonergic regulation of aging.