Learning from boundlessness: epistemic shifts towards a holistic worldview following psychedelic experiences
npj Mental Health Research January 29, 2026 E. K. Argyri, F. Fraser, S. Schilling et al.
Psychedelic experiences can catalyze transformative shifts in worldview, particularly through integrating self-transcendent states. In a mixed-methods study of 90 participants, recalled awe from acute psychedelic experiences—specifically its vastness and connectedness components—was positively associated with greater perceived self-other overlap afterward. Thematic analysis identified three clusters of epistemic change: expanded awareness and openness to complexity, dissolution of societal and natural boundaries, and increased prosociality, compassion, and acceptance of difference. These patterns suggest that boundary-expanding experiences promote reflective meaning-making toward more holistic, interconnected frameworks for understanding self, others, and the world. Further research is needed to develop culturally attuned integration resources.