An online survey of 159 people who experienced difficulties lasting more than one day after using psychedelic drugs in the past 2–10 years found that social disconnection (72%), anxiety and panic attacks (68%), and existential struggle (65%) were the most common problems. Anxiety and panic attacks were rated as most severe, while existential struggle and diminished self-esteem lasted the longest, with average durations exceeding 15 months. Self-education was the most frequently used coping strategy for social disconnection and existential struggle, professional therapy worked best for depression and diminished self-esteem, and peer or family support helped most with anxiety and panic attacks. The findings point to the need for diverse support systems combining professional, educational, and community resources.
Psychedelic experiences can catalyze transformative shifts in worldview, particularly through integrating self-transcendent states. In a mixed-methods study of 90 participants, recalled awe from acute psychedelic experiences—specifically its vastness and connectedness components—was positively associated with greater perceived self-other overlap afterward. Thematic analysis identified three clusters of epistemic change: expanded awareness and openness to complexity, dissolution of societal and natural boundaries, and increased prosociality, compassion, and acceptance of difference. These patterns suggest that boundary-expanding experiences promote reflective meaning-making toward more holistic, interconnected frameworks for understanding self, others, and the world. Further research is needed to develop culturally attuned integration resources.