Increased sensitivity to strong perturbations in a whole-brain model of LSD
bioRxiv Preprint Server January 5, 2021 Beatrice M. Jobst, Selen Atasoy, Adrián Ponce-Alvarez et al. 1 citation preprint
LSD alters brain dynamics by shifting the brain's global working point further from a stable equilibrium, as shown by consistently higher Perturbational Integration Latency Index (PILI) values after intake. Using a whole-brain computational model perturbed in silico, the largest differences were found in the limbic, visual, and default mode networks. Greater variability of PILI values across brain regions under LSD indicates higher response diversity to external perturbations. These findings provide insights into the brain-wide dynamical changes underlying the psychedelic state and suggest possible clinical applications for psychiatric disorders.