AVALIAÇÃO IN SÍLICO DAS POSSÍVEIS ATIVIDADES FARMACOLÓGICAS E TOXICOLÓGICAS DOS COMPOSTOS SECUNDÁRIOS QUE COMPÕEM A BEBIDA AYAHUASCA: BANISTERIOPSIS CAAPI E PSYCHOTRIA VIRIDIS
Revista Ibero-Americana de Humanidades, Ciências e Educação May 20, 2026 Maysa Cruz Lima Feitosa, Bernardo Melo Neto, Joubert Aires de Sousa
Ayahuasca is a beverage of indigenous origin made from Banisteriopsis caapi, which contains β-carboline alkaloids (harmine, harmaline, tetrahydroharmine), and Psychotria viridis, which contains N,N-dimethyltryptamine (DMT). The β-carbolines inhibit monoamine oxidase, enabling oral DMT bioavailability and characteristic psychoactive effects. This study analyzed the secondary compounds of the plants to examine pharmacokinetic and toxicological information. Molecular structures from PubChem were assessed using Swiss Target Prediction, Protox 3.0, and PreADMET platforms. The compounds show significant pharmacological potential but also toxicological risks that should not be overlooked, reinforcing the need for further in vivo and clinical studies.