Effects of Hallucinogens on Neuronal Activity.
Current topics in behavioral neurosciences January 1, 2018 L Lladó-pelfort, P Celada, M S Riga et al. 18 citations
Hallucinogens and noncompetitive NMDA receptor antagonists alter cortical activity in similar ways, including increased pyramidal neuron firing and reduced low-frequency oscillations in the prefrontal cortex. Noncompetitive NMDA receptor antagonists like PCP also increase c-fos expression in excitatory neurons, particularly in the thalamus, by preferentially blocking NMDA receptors on GABAergic neurons of the reticular nucleus. It remains unknown whether serotonergic hallucinogens similarly affect thalamocortical networks. Both classes of agents disrupt prefrontal cortex activity, and this disruption is reversed by classical and atypical antipsychotic drugs, suggesting a link between hallucinogen-induced perceptual disruption and antipsychotic efficacy.