Psychedelic Medicines in Major Depression: Progress and Future Challenges.
Advances in experimental medicine and biology January 1, 2021 Jose Carlos Bouso, Genís Ona, Rafael G Dos Santos et al. 6 citations
Research on psychedelic drugs for therapeutic use has grown, driven by the need for innovative psychiatric treatments. Clinical trials have assessed psilocybin and ayahuasca for mental disorders including major depression. This chapter reviews the history and terminology of psychedelic research, analyzes recent clinical trials administering these drugs to patients, describes neurobiological mechanisms that may underlie therapeutic effects, and notes that psychedelics are commonly used as adjuncts to psychotherapy. The chapter concludes by suggesting future challenges for this field.