Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review.
Journal of psychiatric research May 1, 2021 Bruno Romeo, Marianne Hermand, Amélie Pétillion et al. 74 citations
A systematic review of 20 studies examined factors predicting response to psychedelic treatments for psychiatric and addictive disorders. The main predictor of a positive response across alcohol and tobacco use disorders, treatment-resistant depression, and anxiety and depressive symptoms in patients with life-threatening cancer was the intensity of the acute psychedelic experience. This factor did not predict response for obsessive-compulsive disorder. Possible mechanisms include modulation of the serotoninergic system via 5-HT2A receptor agonism, disruption and reintegration of the default mode network, or anti-inflammatory effects.