Three-day blues after ecstasy/MDMA use: Evidence from a longitudinal and daily analysis in the European nightlife scene.
Drug and alcohol dependence September 12, 2025 Matthijs Blankers, Ruben Van Beek, Desirée Spronk et al. 1 citation
In the three days after using ecstasy/MDMA, young adults who regularly use the drug report a small but significant drop in mental well-being, even after accounting for other substance use, sleep, and baseline depression or anxiety. Cocaine co-use and poor sleep further worsened the effect. No similar drop was seen after use of other common substances. The findings suggest the post-acute mood decline is specifically linked to ecstasy/MDMA, not just party or lifestyle factors.