The relationship between 3,4-methylenedioxymethamphetamine (MDMA) use in young adulthood and anxiety or depressive disorders in the mid-30s: Findings from the Victorian Adolescent Health Cohort Study.
Addiction (Abingdon, England) December 1, 2025 Zachary Bryant, Kirsten Morley, Jessica A Kerr et al.
MDMA (Ecstasy) use in early adulthood appears to be associated with higher odds of anxiety disorders by the mid-30s, but not with depressive disorders. Compared with non-users, those who reported past-year MDMA use had 1.73 times the odds of an anxiety disorder; persistent use at two or more waves was linked to 2.05 times the odds, infrequent use to 2.11 times, and frequent use to 2.56 times the odds. These findings come from a longitudinal population-based study in Victoria, Australia, following 1,943 adolescents into their mid-30s.