Influence of adrenalectomy on the gut microbiome and MDMA-induced hyperthermia.
European journal of pharmacology April 15, 2023 Amal Aburahma, Srishti Rana, Ray Larsen et al. 5 citations
MDMA (Ecstasy, Molly, or X) can cause life-threatening hyperthermia. In rats, removing the adrenal glands reduced the temperature increase after MDMA, and giving norepinephrine or corticosterone partially restored it. MDMA also changed the gut microbiome, altering the balance of bacterial groups like Firmicutes, Bacteroidetes, Actinobacteria, Verrucomicrobia, and Proteobacteria. These results indicate a link between the adrenal system, gut bacteria, and MDMA-induced hyperthermia.