Psychedelic Medicine
April 21, 2025
Luke Flynn, Mary Rondeau, Martin Krsak et al.
1 citation
A 6-week community-based group ketamine-assisted psychotherapy (KAP) program reduced symptoms of trauma, anxiety, and depression in a sample of 16 first responders and frontline health care workers experiencing work-related stress. Participants completed the program in small groups of three to six. Pre- and post-treatment comparisons using standardized measures showed significant reductions in trauma, anxiety, and depression scores. The findings suggest that group KAP may be a useful treatment for work-related stress, though further formal evaluation is needed.
Psychotherapy and psychosomatics
June 19, 2026
Judith Rohde, Tyler M Moore, Kathryn Walker et al.
A systematic review and individual participant data meta-analysis of 12 studies (533 participants) found that higher baseline PTSD severity was the most robust predictor of symptom reduction after combined ketamine and psychotherapy. More psychotherapy sessions, more ketamine sessions, and shorter treatment duration were also associated with greater improvement, but these findings are tentative because most studies were of poor quality. The analysis showed that for each additional psychotherapy session, PTSD symptoms improved by an average of 1.03 points on the PCL-5, and for each additional ketamine session, improvement was 1.15 points. The results require confirmation in well-designed prospective trials.
Therapeutic Advances in Psychopharmacology
October 1, 2025
Luke Flynn, Martin Krsak, Mary Rondeau et al.
A group ketamine-assisted psychotherapy program for frontline healthcare workers and first responders reduced symptoms of anxiety, depression, trauma, and burnout. Median scores on the GAD-7 (anxiety) dropped from 9.5 to 6, PHQ-9 (depression) from 12 to 5, and PCL-5 (trauma) from 27 to 10, all with statistically significant improvements. The Maslach Burnout Inventory also improved across all subcomponents. The seven-week program included three ketamine sessions and four group psychotherapy sessions. Adverse events were rare, suggesting this model may be a viable intervention for job-related stress, though larger controlled studies are needed.