Effects of Nostoc commune extract on the cerebral oxidative and neuroinflammatory status in a mice model of schizophrenia
Biochemistry and Biophysics Reports December 8, 2023 Parisa Jahani Bahnamiri, Akbar Hajizadeh Moghaddam, Mojtaba Ranjbar et al. 3 citations
An extract from the cyanobacterium Nostoc commune (NCE) given orally to mice at 70 or 150 mg/kg per day for 14 days reduced anxiety- and depression-like behaviors caused by ketamine, a model of schizophrenia. In the cerebral cortex, NCE lowered dopamine levels, reduced the oxidative stress marker malondialdehyde, and decreased the inflammatory cytokines IL-6 and TNF-α. It also increased the antioxidant glutathione and the activity of catalase, superoxide dismutase, and glutathione reductase. The findings suggest that NCE may protect the brain from schizophrenia-like behavioral, oxidative, and inflammatory damage.