Exploring Predictors of Ketamine Response in Adolescent Treatment-Resistant Depression
Journal of Child and Adolescent Psychopharmacology January 3, 2024 Alice Lineham, Victor J. Avila‐quintero, Michael H. Bloch et al. 15 citations
Ketamine works as a rapid antidepressant for some but not all patients. In adolescents with treatment-resistant depression, those who had tried fewer antidepressant medications and augmentation treatments, had a shorter current depressive episode, and were currently taking a selective serotonin reuptake inhibitor (rather than a serotonin–norepinephrine reuptake inhibitor) were more likely to experience symptom improvement one and seven days after a single dose of ketamine. These findings are preliminary due to the small sample and multiple analyses, and more research is needed before using such predictors in clinical practice.