Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review
Frontiers in Behavioral Neuroscience December 3, 2021 Michael Colla, Hanne Scheerer, Steffi Weidt et al. 9 citations
Ketamine's rapid antidepressant effects challenge traditional theories that focus on monoaminergic pathways. Current research explores mechanisms including glutamatergic disinhibition, neurotrophic, and neuroplastic effects. Despite extensive study, ketamine has not yet led to new therapies beyond itself, and significant knowledge gaps and study limitations remain.