Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration
International Journal of Molecular Sciences March 20, 2020 David P. Herzog, Ratnadevi M. Mellema, Floortje Remmers et al. 9 citations
In a genetically modified mouse line (Arc-CreERT2 × CAG-Sun1/sfGFP), males and females differed in sociability and anxiety tests. The rapid-acting antidepressants ketamine and (2R,6R)-hydroxynorketamine (HNK) produced opposite effects in the forced swim test depending on sex: in males, ketamine reduced immobility compared to (2R,6R)-HNK, indicating a different behavioral profile between the two drugs. At the molecular level, female mice treated with ketamine showed increased Bdnf mRNA levels, a change previously observed in males.