Ketamine and Depression: A Review
International Journal of Transpersonal Studies July 1, 2014 Wesley C. Ryan, Cole J. Marta, Ralph J. Koek 5 citations
Intravenous ketamine is a fast-acting treatment for treatment-resistant depression in both unipolar and bipolar forms. Its benefits last days, longer in unipolar depression, and it may reduce suicidality, though data are limited. Strategies to extend effects—multiple doses, maintenance, or additional medications—have shown mixed results. Alternative routes (intramuscular, intranasal, oral) show promise but lack sufficient data. Adverse effects are mainly mild, transient dissociative and sympathomimetic symptoms, indicating good tolerability. Ketamine's unique properties could shift depression treatment paradigms.