A digital mindfulness-based intervention for prenatal insomnia reduced insomnia symptoms in pregnant women with subthreshold to clinical insomnia. In a randomized trial with 160 women, those receiving the six-week digital program plus standard care showed greater improvement in insomnia symptoms immediately after the intervention and in the third trimester compared to standard care alone, with a moderate effect size. Benefits were not sustained at 42 days postpartum. The intervention also increased the likelihood of insomnia remission by the third trimester. Changes in sleep-specific worry and presleep arousal mediated the effect. Most secondary outcomes, including sleep quality and mood, did not differ significantly between groups.
Global signal regression (GSR), a common preprocessing step in fMRI analysis, affects brain activity patterns differently depending on the anesthetic agent used. Using fMRI data from patients under general anesthesia, the work shows that GSR alters specific network connections under propofol but broadly reduces connectivity differences under sevoflurane. Network topology analyses reveal that GSR minimally affects propofol-induced changes in graph theoretical measures but significantly diminishes sevoflurane-related network alterations. These findings indicate that GSR's impact on functional brain organization is anesthetic-specific, with sevoflurane-induced changes being particularly sensitive to global signal removal. The results suggest that GSR should be applied cautiously when comparing different anesthetic agents.