Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes.
Psychopharmacology October 27, 2025 Nina Gregoire, Ethan Klukas, Kimberley Kaseweter et al.
Three personality profiles—Easygoing Extraverts, Average, and Reserved Introverts—emerged among 184 patients receiving ketamine-assisted therapy at a Canadian clinic. Reserved Introverts had more severe baseline depression and anxiety. All profiles showed improvements in depression and anxiety one week after treatment, but personality did not predict differential symptom change. Patients with a trauma history experienced greater reductions in depression and improvements in physical quality of life than those without. Personality relates to baseline mental health severity but not short-term treatment response, while trauma history may indicate greater benefit from ketamine therapy.