Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression.
Imaging neuroscience (Cambridge, Mass.) January 1, 2025 Brandon Taraku, Jason S Nomi, Artemis Zavaliangos-Petropulu et al.
Ketamine treatment alters how brain networks dynamically interact in people with treatment-resistant depression. After four ketamine infusions over two weeks, patients spent less time in a visual-network brain state and more time in a central-executive-network state. Transitions between the salience network and central executive network increased, while salience-to-visual transitions decreased. Reduced time in the salience-network state was linked to less rumination. Before treatment, depressed patients differed from healthy controls in these same dynamic patterns, suggesting ketamine may shift network dynamics toward a healthier profile.