A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression.
Frontiers in psychiatry January 1, 2021 Georgios Mikellides, Panayiota Michael, Lilia Psalta et al. 17 citations
Both intramuscular ketamine and repetitive transcranial magnetic stimulation (rTMS) effectively reduced depressive and anxiety symptoms in patients with treatment-resistant depression. In a naturalistic clinical setting, 24 patients received either eight sessions of ketamine or 30 sessions of left dorsolateral prefrontal cortex intermittent theta-burst stimulation. Both groups showed significant improvement from pre- to post-treatment on three clinical assessments, with no significant differences between the therapies in symptom reduction, remission, or response rates, indicating they were equally effective in this limited sample.