Ketamine abrogates sensorimotor deficits and cytokine dysregulation in a chronic unpredictable mild stress model of depression.
Psychopharmacology January 1, 2022 Edem Ekpenyong Edem, Collins-Kevin Chukwudi Anyanwu, Kate Eberechukwu Nebo et al. 9 citations
Chronic unpredictable mild stress in mice induces depressive-like behaviors and impairs sensorimotor performance, accompanied by elevated neuroinflammation. Ketamine hydrochloride, given in a sequential exposure regimen, improves sensorimotor deficits and reduces depressive-like behaviors. It also decreases microglial activation and lowers pro-inflammatory cytokine levels in the cerebrum, spinal cord, and cerebellum. The findings indicate that ketamine therapy can enhance sensorimotor function alongside its antidepressant effects, likely through modulation of central nervous system inflammation.