2 papers in the library · 17 citations · publishing 2016-2023
Neuropsychiatric disease and treatment January 1, 2016 Yuan-Yuan Lu, Chieh-Hsin Lin, Hsien-Yuan Lane 17 citations
A 26-year-old man who abused ketamine by inhalation for 12 months developed manic-like symptoms after using the drug. This case suggests a possible relationship between manic symptoms and ketamine abuse, and may be the first report of mania following recreational ketamine use.
Neuropharmacology February 1, 2023 Yu-Jung Cheng, Chieh-Hsin Lin, Hsien-Yuan Lane
A review compares the antidepressant mechanisms of sarcosine, benzoate, ketamine, esketamine, and arketamine. These compounds modulate N-methyl-d-aspartate glutamate receptors (NMDARs) and reduce brain inflammation by inhibiting microglial activity. Though they act differently as antagonists or coagonists of NMDARs, all have shown efficacy in animal models or human trials. The review concludes that these drugs act as both NMDAR modulators and anti-inflammatory agents, making them potentially effective for treating depression.