Case report: Effectiveness of brexpiprazole and esketamine/ketamine combination: A novel therapeutic strategy in five cases of treatment-resistant depression
Frontiers in Psychiatry July 22, 2022 Lai Fong Chan, Luke Sy-Cherng Woon, Nuur Asyikin Mohd Shukor et al. 2 citations
For patients with treatment-resistant depression who do not achieve functional recovery after multiple pharmacotherapies, combining brexpiprazole with esketamine or ketamine may offer a more rapid and effective augmentation strategy. This case series describes five complex cases of unipolar and bipolar treatment-resistant depression where conventional treatments failed to manage high-risk suicidal behavior or restore function. The authors discuss potential synergistic mechanisms of this novel combination, patient and clinical factors affecting response, challenges encountered, and implications for future practice and research.