Sub-Anesthetic Ketamine Administration Decreases Deviance Detection Responses at the Cellular, Population- and Mesoscale Levels.
The European journal of neuroscience April 1, 2026 Maria Isabel Carreño-muñoz, Alessandra Ciancone Chama, Pegah Chehrazi et al.
A specific biphasic spiking response in a subpopulation of primary auditory cortex (A1) neurons is elicited by deviant, but not standard, sounds; the second peak is abolished by acute sub-anesthetic injection of ketamine, a partial non-competitive NMDA receptor antagonist. The posterior parietal cortex (PPC) responds to deviant, but not repetitive, sounds, and this response depends on intact NMDA receptor-mediated signaling. Weighted phase lag index (wPLI) analyses show functional connectivity between A1 and PPC following deviant detection, which is impaired by ketamine administration. These findings provide novel insights into NMDA receptor-dependent mechanisms underlying auditory novelty processing.