Case Report: Intranasal esketamine combined with a form of generative artificial intelligence in the management of treatment-resistant depression.
Frontiers in psychiatry January 1, 2025 Alexandre Fraichot, Sophie Favre, Hélène Richard-Lepouriel 1 citation
A 37-year-old patient with treatment-resistant depression received intranasal Esketamine (84 mg) and used ChatGPT-4 to generate images and interpretations of his dissociative experiences, supported by a nurse. Depression severity was measured with the Montgomery-Åsberg Depression Rating Scale (MADRS). The patient achieved remission, with MADRS scores declining by 50% by the third session and indicating mild depression or euthymia in the eight subsequent sessions. The patient reported that the artificial intelligence-generated images and interpretations helped him create a timeline of his experiences. The case report suggests combining intranasal Esketamine with generative artificial intelligence may be effective, but further research is needed.