Gas Chromatography-Mass Spectrometry Method for the Quantitative Identification of 23 New Psychoactive Substances in Blood and Urine.
Journal of analytical toxicology June 1, 2019 Lorna A Nisbet, Fiona M Wylie, Barry K Logan et al. 40 citations
A validated gas chromatography-mass spectrometry (GC-MS) method can simultaneously quantify 23 new psychoactive substances (NPSs) in blood and urine, including NBOMe compounds that are usually analyzed by liquid chromatography-tandem mass spectrometry. The method, which uses solid-phase extraction and derivatization, met SWGTOX guidelines for bias, precision, linearity, and stability. When applied to reanalyze 12 blood samples from eight cases where 25I-NBOMe, 25C-NBOMe, methoxetamine, and methylone had previously been detected, the method quantitatively detected these drugs in 75% of samples, with 42% containing either 25C-NBOMe or 25I-NBOMe. This approach offers a practical alternative for laboratories lacking specialized equipment.