NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS
Bulletin of Pharmaceutical Sciences. Assiut University May 26, 2026 R. Shafik, N. Eshba, M. El-Semary et al.
Researchers designed new chemical compounds that combine features of mescaline and phencyclidine (PCP) to explore their potential interaction with PCP receptors in rat brains. The proposed molecules are structural hybrids, including variants with an N-(2-chloroethyl) group that could allow them to bind permanently to receptors. However, the actual effects of mescaline and the potential blocking activity of these new compounds at central PCP receptors have not yet been tested.