Possible Involvement of Hallucinogenic Effects in the Aversive Effects Induced by Kappa‐Opioid and 5‐ HT 2A / 2C Receptor Agonists in Mice
Neuropsychopharmacology Reports November 23, 2025 Hideaki Kato, Yoshimi Ichimaru, Masaaki Kurihara et al. 1 citation
A simple behavioral test in mice may help regulators quickly identify new hallucinogenic drugs. Mice given the hallucinogen-like compound DOI showed aversive effects in a conditioned place aversion test and abnormal behavior in a marble-burying test. These responses likely stem from the drug's hallucinogenic properties. The findings suggest that such rodent tests could serve as a rapid, accurate screening method for designating new psychoactive substances as controlled drugs, aiding prevention of drug abuse.