Molecular Insight into the Interaction between Different Classes of Psychoplastogens and Serotonin 5-HT2A Receptor
International Journal of Science and Research (IJSR) April 3, 2025 David Nisenboim
A new class of fast-acting antidepressants called psychoplastogens promotes significant and long-lasting changes in neural plasticity after a single dose, unlike conventional treatments. This study developed a novel classification of psychoplastogens based on their structural models and performed docking experiments to measure their binding energy to the serotonin 5-HT2A receptor. A correlation was identified between the hallucinogenic effect of some psychoplastogens and their affinity to the 5-HT2A receptor. The authors then predicted binding affinities of newly generated psychoplastogens, validated with their methodology, aiming to guide future in vitro and clinical research on these drugs.