International Journal of Molecular Sciences
February 14, 2022
Bronislav Jurásek, Silvie Rimpelová, Martin Babor et al.
7 citations
A sample of the dissociative anesthetic methoxphenidine from the black market contained an unusual bromo- and chloro-zincate anion impurity. In vitro cytotoxicity tests on kidney, liver, and bladder cell lines showed that the street sample was markedly more toxic than a pure methoxphenidine standard, suggesting the impurity caused the increased toxicity. A method using X-ray powder diffraction (XRPD) was developed to identify such anions and distinguish different crystalline forms of methoxphenidine, providing additional data not captured by routine analysis.
Powder Diffraction
August 22, 2017
J. Maixner, Bronislav Jurásek, Michal Himl et al.
2 citations
The X-ray powder diffraction pattern of 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one hydrochloride is reported, providing its unit-cell parameters and space group. The compound crystallizes in the monoclinic space group P21 with two molecules per unit cell. All observed diffraction lines were indexed and matched this space group, and no impurities were detected.
Powder Diffraction
December 1, 2025
Analio Dugarte-Dugarte, Jacco van de Streek, Graciela Dı́az de Delgado et al.
The crystal structures of two arylcyclohexylamine derivatives, methoxmetamine hydrochloride (MMXE·HCl) and methoxetamine hydrochloride (MXE·HCl), were determined using laboratory X-ray powder diffraction data. Both compounds are known for anesthetic and sedative effects and have been used illicitly as recreational drugs. Structure determination was performed with DASH software and Rietveld refinements with TOPAS Academic, yielding monoclinic unit cells. For MMXE·HCl, the parameters were a = 15.0429(5) Å, b = 14.0721(5) Å, c = 6.5716(2) Å, β = 90.9864(14)°, V = 1,390.91(8) ų, with Z = 4 and space group P2₁/n. For MXE·HCl, the parameters were a = 8.7772(5) Å, b = 9.9528(7) Å, c = 8.5841(6) Å, β = 100.276(3)°, V = 737.