ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist.
Life sciences November 17, 2000 C Acuña-castillo, C Scorza, M Reyes-Parada et al. 3 citations
ALEPH-2, a phenylisopropylamine derivative with claimed anxiolytic and hallucinogenic effects, acts as a partial agonist on the 5-HT2A receptor with potency similar to serotonin, but as a full agonist on the 5-HT2C receptor, where it is about 15-fold less potent than serotonin. The antagonist ritanserin blocks responses to both serotonin and ALEPH-2 equally, though the 5-HT2A receptor is more sensitive to ritanserin than the 5-HT2C receptor.