Evaluation of Cytotoxic, Necrotic, Apoptotic, and Autophagic Effects of Methamphetamine and 3,4-Methylenedioxymethamphetamine on U-87 MG (Glial) and B104-1–1 (Neuronal) Cell Lines
Neurotoxicity Research October 1, 2022 Asieh Hosseini, Seyed Mohammad-Hossein Shetab-Boushehri, Seyed Vahid Shetab-Boushehri 3 citations
Methamphetamine (MA) and MDMA show stronger cytotoxic effects on neuronal and glial cells. MDMA causes more potent mitochondrial toxicity and stronger necrotic and autophagic effects than MA in both cell lines. While MDMA induces a stronger apoptotic effect than MA in glial cells, both drugs have equal apoptotic effects on neuronal cells. MDMA also produces greater mitochondrial toxicity and stronger necrotic, apoptotic, and autophagic effects in neuronal cells compared to glial cells.