MDMA and Pavlovian Fear Memory: Dose‐Effect Analysis
The FASEB Journal April 1, 2019 Madeline M. Pantoni, Stephan Anagnostaras
Low to moderate doses of MDMA (less than 3 mg/kg), typical of recreational or therapeutic use, may not impair learning and memory as severely as high doses. In mice trained with a Pavlovian fear conditioning paradigm, doses from 0.1 to 8 mg/kg were tested. Immediate memory and long-term contextual and cued memory were assessed one week later. The findings help determine whether low doses are therapeutically viable without adverse cognitive effects.