5-methoxy-N,N-di(iso)propyltryptamine hydrochloride (Foxy)-induced cognitive deficits in rat after exposure in adolescence.
Physiology & behavior May 3, 2011 David M Compton, Kerri L Dietrich, Melissa C Selinger et al. 21 citations
The recreational hallucinogen 5-MeO-DIPT (Foxy or Methoxy Foxy) impairs cognitive flexibility in rats when administered during adolescence. Rats given repeated injections of 5 or 20 mg/kg of the drug during one of two adolescent periods were later tested as adults on spatial memory and nonspatial tasks. Drug-treated rats performed as well as controls on spatial navigation to a fixed goal, but were markedly inferior when the goal moved to a new location and on a response learning task, indicating reduced ability to adapt to changing demands. The drug also reduced serotonin activity in the forebrain, similar to MDMA, suggesting it compromises serotonergic systems.