Therapeutic potential of psilocybin in the pharmacological treatment of obsessive-compulsive disorder: a scoping review protocol.
Open Science Framework July 9, 2026 Raul Edison Luna Lazo, Nicole Milagritos Cardoso Azorza, Jatziri Yanina Vilca Yanac et al.
Psilocybin, a classic psychedelic that acts on serotonin 5-HT2A receptors, is being investigated as a potential treatment for obsessive-compulsive disorder (OCD), a chronic condition marked by intrusive thoughts and repetitive behaviors. Many patients do not respond adequately to first-line treatments like selective serotonin reuptake inhibitors and cognitive behavioral therapy. This scoping review, following JBI recommendations and PRISMA-ScR guidelines, will systematically search PubMed, Scopus, and Web of Science for preclinical and clinical studies on psilocybin or psilocin for OCD. The review aims to map current evidence, identify knowledge gaps, and guide future research, particularly for treatment-resistant patients.