Concise Synthesis of N,N -Dimethyltryptamine and 5-Methoxy- N,N -dimethyltryptamine Starting with Bufotenine from Brazilian Anadenanthera ssp
Natural Product Communications April 1, 2015 Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto et al. 3 citations
Bufotenine, a compound found in seeds of the Anadenanthera tree native to the Brazilian cerrado, was extracted using an acid-base method. The researchers developed a new, short process to convert bufotenine into N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine, involving a novel bufotenine-aminoborane complex. They also established a straightforward method to produce 5-hydroxy-N,N,N-trimethyltryptamine from bufotenine. This work presents bufotenine as a source for producing N,N-dimethyltryptamines for pharmacological, toxicological, or synthetic use.