BEHAVIOURAL CHANGES INDUCED BY N,N‐DIMETHYLTRYPTAMINE IN RODENTS
British Journal of Pharmacology May 1, 1980 P. Jenner, C.d. Marsden, C.m. Thanki 38 citations
In rodents pretreated with pargyline, DMT caused a dose-dependent set of behaviors including hyperactivity, prostration, hindlimb abduction, mild tremor, Straub tail, retropulsion, and jerking. Unlike l-tryptophan or quipazine, DMT did not produce forepaw treading or head-weaving and caused only mild tremor. The hyperactivity component was potentiated by cyproheptadine, methergoline, and mianserin; inhibited by cinanserin, haloperidol, pimozide, methiothepin, and propranolol; and unaffected by 501C67-sulphate and methysergide. Other behavioral changes were mostly unaffected by these drugs, except propranolol reduced most effects and methergoline decreased prostration duration. Phenoxybenzamine and haloperidol enhanced prostration. DMT did not induce circling in mice with unilateral 6-hydroxydopamine lesions. The syndrome appears to have two components: hyperactivity, possibly mediated by dopamine, and other behaviors that are not.