Ayahuasca
Psychedelics as Psychiatric Medications March 1, 2023 Daniel Perkins, Simon G. D. Ruffell, Jerome Sarris
Ayahuasca, a psychedelic plant brew from the Amazon basin, is made from the ayahuasca vine (Banisteriopsis caapi) and DMT-containing leaves like chacruna (Psychotria viridis). Its harmala alkaloids act as MAOIs, preventing DMT breakdown, while DMT modulates serotonin and dopamine signaling. Used for centuries by indigenous tribes for healing, recent research suggests effectiveness for depression, anxiety, and addiction. Interest has surged, with many 'ayahuasca tourists' seeking treatment, and clinical research raises ethical issues around medicalization.